Hereditary motor sensory neuropathy pdf

Find more resources in the Cochrane Community. Muscle hereditary motor sensory neuropathy pdf and loss of sensation are caused by destruction of nerve fibres that go to the muscles or skin. An intervention that to all intents and purposes appears to be the same as that which is being assessed but which does not have the active component being assessed.

The trials in adults included a total of 622 people. Clinical trials are research studies involving people who use services, which compare a new or different type of treatment with the best treatment currently available. They test whether the new or different treatment is safe, effective and any better than what already exists. No matter how promising a new treatment may appear during tests in a laboratory, it must go through clinical trials before its benefits and risks can really be known.

In the broader healthcare context it refers to any attempt to synthesise the results of more than one study on a particular topic area. We also collected information on disability, nerve conduction studies, sensation, muscle strength, quality of life and harmful effects of vitamin C. In children, the CMTNS was not reported, as it is a measure developed for adults with CMT. A systematic, well-planned investigation of a healthcare problem. A way of expressing the chance of an event taking place, expressed as the number of events divided by the total number of observations or people. This measure is good no matter the incidence of events ie common or infrequent.

Any factor, recognised or not, that distorts the findings of a study. There is high-quality evidence for adults and low-quality evidence for children that vitamin C does not improve the course of CMT1A. 12 or 24 months may not have been long enough to detect effects of treatment. The term research means different things to different people, but is essentially about finding out new knowledge that could lead to changes to treatments, policies or care.

The attempt to derive generalisable new knowledge by addressing clearly defined questions with systematic and rigorous methods. A measure of the effect of an intervention that is relevant to health care. According to low-quality evidence, ascorbic acid does not improve the course of CMT1A in children. The molecular basis of several CMT subtypes has been clarified during the last 20 years. Since slowly progressive muscle weakness and sensory disturbances are the main features of these syndromes, treatments aim to improve motor impairment and sensory disturbances to improve abilities. Pharmacological treatment trials in CMT are rare.